Injuries to their already-thin secondary also played a role against Buffalo.
Newton threw a 40-yard touchdown to Ted Ginn Jr. on Carolina's first drive of the second half, but the Panthers' deep game otherwise struggled.
The Panthers fell to 2-14 in games decided by 7 points or less under coach Ron Rivera,Jerseys NFL China.
In the latest,Jerseys NFL China, they gave up a last-second touchdown to the Buffalo Bills in a 24-23 defeat Sunday.
"Everything that could've gone wrong did," Carolina linebacker Thomas Davis said.
Carolina lost cornerback Josh Thomas to a concussion in the first half and safety Charles Godfrey to a right Achilles tendon injury in the second,cheap nfl jerseys online. Reserve defensive backs Josh Norman and Quintin Mikell were also slowed by injuries during the game.
Manuel then led a nine-play, 80-yard drive in 96 seconds, finding Stevie Johnson in the left corner of the end zone for a 2-yard touchdown pass with 2 seconds left.
ORCHARD PARK, N.Y. (AP) ? The Carolina Panthers' close losses are becoming more and more painful.
The Panthers opened up a 23-17 lead thanks to some strong plays by Cam Newton, who finished 21 of 38 for 229 yards, two touchdowns and an interception. But he couldn't turn two Bills turnovers deep in Buffalo territory into touchdowns.
The Panthers failed on multiple opportunities to close out the Bills and rookie quarterback EJ Manuel despite forcing two fourth-quarter turnovers by Buffalo. Carolina had to settle for field goals from Graham Gano both times.
"This is like going to the dentist and getting several teeth pulled without any anesthesia,Adrian Wilson Cardinals Jersey, laughing gas, nothing," said Panthers receiver Steve Smith. "It's tough and it's sickening."
"Our efficiency in the red zone has to be better, starting with me," Newton said.
It was the first victory for the new-look Bills under Manuel and coach Doug Marrone. The win came on a day when the Bills honored their 28-member Wall of Fame ? a group that includes Hall of Famers Jim Kelly, Thurman Thomas and Marv Levy ? during a halftime ceremony, and a week after the Bills squandered a last-second lead in a 23-21 season-opening loss to the New England Patriots.
Manuel became the fifth NFL rookie since 1960 to engineer a fourth-quarter comeback in his first or second game.
Bills defensive end Mario Williams set a team record with 4